新建一个项目，添加命令按钮和标签各一个，加上以下代码，然后运行.... 
Option Explicit 
' Copyright ? 1997 by Desaware Inc. All Rights Reserved 
Dim DemoFile$ 
Private Const NORMAL_PRIORITY_CLASS = &H20 '如果进程位于前台，则基本值是9；如果在后台，则优先值为7 
Private Const INFINITE = &HFFFFFFFF 
Private Const WAIT_TIMEOUT = &H102& '对象保持未发出信号的状态，但等待超时时间已经超过 

'说明∶PROCESS_INFORMATION结构由CreateProcess函数将关于新建立的进程和 
'主要线索的信息写入其中成员变量 
Private Type PROCESS_INFORMATION ' 
hProcess As Long 
hThread As Long 
dwProcessId As Long 
dwThreadId As Long 
End Type 

'说明∶STARTUPINFO结构用在CreateProcess函数中指定为新进程建立的新窗口的主要属性。这一 
'一信息影响由CreateWindows函数建立的第一个窗口 
Private Type STARTUPINFO 
cb As Long 
lpReserved As String 
lpDesktop As String 
lpTitle As String 
dwX As Long 
dwY As Long 
dwXSize As Long 
dwYSize As Long 
dwXCountChars As Long 
dwYCountChars As Long 
dwFillAttribute As Long 
dwFlags As Long 
wShowWindow As Integer 
cbReserved2 As Integer 
lpReserved2 As Long 
hStdInput As Long 
hStdOutput As Long 
hStdError As Long 
End Type 

Private Declare Function CloseHandle Lib "kernel32" (ByVal hObject As Long) As Long 
Private Declare Function WaitForSingleObject Lib "kernel32" (ByVal hHandle As Long, ByVal dwMilliseconds As Long) As Long 
Private Declare Function CreateProcess Lib "kernel32" Alias "CreateProcessA" (ByVal lpApplicationName As String, ByVal lpCommandLine As String, ByVal lpProcessAttributes As Long, ByVal lpThreadAttributes As Long, ByVal bInheritHandles As Long, ByVal dwCreationFlags As Long, lpEnvironment As Any, ByVal lpCurrentDirectory As String, lpStartupInfo As STARTUPINFO, lpProcessInformation As PROCESS_INFORMATION) As Long 
Private Declare Function WaitForInputIdle Lib "user32" (ByVal hProcess As Long, ByVal dwMilliseconds As Long) As Long 


Private Sub command1_Click() 
Dim res& 
Dim sinfo As STARTUPINFO 
Dim pinfo As PROCESS_INFORMATION 
sinfo.cb = Len(sinfo) 
sinfo.lpReserved = vbNullString 
sinfo.lpDesktop = vbNullString 
sinfo.lpTitle = vbNullString 
sinfo.dwFlags = 0 

Label1.Caption = "正在启动程序" 
Label1.Refresh 
' CreateProcess函数，用于创建一个新的进程 
res = CreateProcess(DemoFile, vbNullString, 0, 0, True, _ 
NORMAL_PRIORITY_CLASS, ByVal 0&, vbNullString, sinfo, pinfo) 
If res Then 
Label1.Caption = "程序正在运行" 
WaitForTerm pinfo 
End If 
Label1.Caption = "程序已经结束" 

End Sub 

Private Sub WaitForTerm(pinfo As PROCESS_INFORMATION) 
Dim res& 
' 等待指定的进程进入空闲状态，,空闲(Idle)指的是进程准备处理 
'一条消息、但目前暂时没有消息需要处理的一种状态 
Call WaitForInputIdle(pinfo.hProcess, INFINITE) 
' 关闭指定进程 
Call CloseHandle(pinfo.hThread) 
Command1.Enabled = False 
Label1.Refresh 
Do 
'等待发出信号 
res = WaitForSingleObject(pinfo.hProcess, 0) 
If res <> WAIT_TIMEOUT Then '如果对象发出了信号 
Exit Do 
End If 
DoEvents 
Loop While True 
Command1.Enabled = True 
Call CloseHandle(pinfo.hProcess) 
End Sub 

Private Sub Form_Load() 
DemoFile = InputBox$("请输入需要运行的程序名", , "C:\WINDOWS\notepad.exe") 
End Sub